Striatal Neurotransmitter Release-related Presynaptic Proteins in L-dopa Induced Dyskinesia in a Model of Parkinsonism

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YALÇIN ÇAKMAKLI G., VURAL A., EREN KOÇAK E., ELİBOL B., Saka E.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, vol.55, no.1, pp.73-79, 2018 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 55 Issue: 1
• Publication Date: 2018
• Doi Number: 10.5152/npa.2017.20531
• Journal Name: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.73-79
• Hacettepe University Affiliated: Yes

Abstract

Introduction: In Parkinson's disease, L-dopa-induced dyskinesia (LID) and motor fluctuations incapacitate patients as much as the disease itself. Many studies demonstrated that postsynaptic alterations and striatal synaptic plasticity changes play a role in LID development. Here, we aimed to study the role of striatal presynaptic proteins in LID pathogenesis.