Iopromdie, a triiodobenzene derivative, is a hydrophilic non-ionic radiocontrast agent. It causes mild side effects such as nausea, vomiting, flushing, tachycardia and hypotension. In this study, liposomes and niosomes containing iopromide were prepared in the gel and liquid crystalline state. The phospholipids used to prepare the liposomes were Phospholipon-100 for the liquid crystalline-state and distearyl posphatidyl choline for the gel state. For the niosomes, the surfactants were (hexadecyl poly-(3)-glycerol) for the gel state and (dialkyl poly-(7)-glycerol ether) for the liquid crystalline state. The vesicles were characterized according to size, encapsulation rate, in vitro release kinetics of iopromide and encapsulation stability. Higuchi kinetics were found to have the best fit for drug release. Niosomes were found to be more stable than liposomes; however; no difference was seen between the gel and liquid crystalline states. In vivo, both liposomes and niosomes interact with plasma proteins, resulting in a loss of lipids and leakage of the drug.