Blockade of sodium channels by phenytoin protects ultrastructure and attenuates lipid peroxidation in experimental spinal cord injury


Kaptanoglu E., Solaroglu I., Surucu H., Akbiyik F. , Beskonakli E.

ACTA NEUROCHIRURGICA, vol.147, no.4, pp.405-412, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 147 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.1007/s00701-004-0447-5
  • Title of Journal : ACTA NEUROCHIRURGICA
  • Page Numbers: pp.405-412

Abstract

Spinal cord injury (SCI) involves a series of pathological events. Abnormal sodium influx has been implicated as one of the key events in the pathophysiology of the SCI. Pharmacological blockade of sodium channels can reduce secondary injury and increase recovery from trauma. The aim of the present study was to show the neuroprotective effect of phenytoin, a sodium channel blocker, after experimental SCI.