Blockade of sodium channels by phenytoin protects ultrastructure and attenuates lipid peroxidation in experimental spinal cord injury


Kaptanoglu E., Solaroglu I., Surucu H., Akbiyik F., Beskonakli E.

ACTA NEUROCHIRURGICA, cilt.147, sa.4, ss.405-412, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 147 Sayı: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1007/s00701-004-0447-5
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.405-412
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Spinal cord injury (SCI) involves a series of pathological events. Abnormal sodium influx has been implicated as one of the key events in the pathophysiology of the SCI. Pharmacological blockade of sodium channels can reduce secondary injury and increase recovery from trauma. The aim of the present study was to show the neuroprotective effect of phenytoin, a sodium channel blocker, after experimental SCI.