Blockade of sodium channels by phenytoin protects ultrastructure and attenuates lipid peroxidation in experimental spinal cord injury

Kaptanoglu E., Solaroglu I., Surucu H., Akbiyik F., Beskonakli E.

ACTA NEUROCHIRURGICA, vol.147, no.4, pp.405-412, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 147 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.1007/s00701-004-0447-5
  • Journal Name: ACTA NEUROCHIRURGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.405-412
  • Hacettepe University Affiliated: Yes

Abstract

Spinal cord injury (SCI) involves a series of pathological events. Abnormal sodium influx has been implicated as one of the key events in the pathophysiology of the SCI. Pharmacological blockade of sodium channels can reduce secondary injury and increase recovery from trauma. The aim of the present study was to show the neuroprotective effect of phenytoin, a sodium channel blocker, after experimental SCI.