Urinary profile of 6 beta-hydroxycortisol in workers exposed to aluminum

Baydar T., Aydin A., Sahin G.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.120, ss.36-41, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 120
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s12011-007-0073-1
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.36-41
  • Anahtar Kelimeler: aluminum, 6 beta-hydroxycortisol, biomarker, enzyme induction, cytochrome P450, CORTISOL, INDICATOR, INDUCTION, EXCRETION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

The aim of the present study was to evaluate whether aluminum exposure may cause alterations of cytochrome P (450)3A4 by measuring the urinary excretion of 6 beta-hydroxycortisol as biomarker. There is a positive correlation between urinary 6 beta-hydroxycortisol and aluminum excretion (p < 0.05). The correlations between occupational duration, smoking habits, and age were also evaluated. The increased excretion of the biomarker suggests that this element may induce formation of cytochrome P (450) in exposed individuals.