Levodopa-Induced Dyskinesia Is Associated with Increased Thyrotropin Releasing Hormone in the Dorsal Striatum of Hemi-Parkinsonian Rats

Cantuti-Castelvetri, Ippolita; Hernandez, Ledia; Keller-McGandy, Christine; Kett, Lauren; Landy, Alex; Hollingsworth, Zane; SAKA TOPÇUOĞLU, ESEN; Crittenden, Jill; Nillni, Eduardo; Young, Anne; Standaert, David; Graybiel, Ann

doi:10.1371/journal.pone.0013861

Levodopa-Induced Dyskinesia Is Associated with Increased Thyrotropin Releasing Hormone in the Dorsal Striatum of Hemi-Parkinsonian Rats

Cantuti-Castelvetri I., Hernandez L. F., Keller-McGandy C. E., Kett L. R., Landy A., Hollingsworth Z. R., ...Daha Fazla

PLOS ONE, cilt.5, sa.11, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 5 Sayı: 11
Basım Tarihi: 2010
Doi Numarası: 10.1371/journal.pone.0013861
Dergi Adı: PLOS ONE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Dyskinesias associated with involuntary movements and painful muscle contractions are a common and severe complication of standard levodopa (L-DOPA, L-3,4-dihydroxyphenylalanine) therapy for Parkinson's disease. Pathologic neuroplasticity leading to hyper-responsive dopamine receptor signaling in the sensorimotor striatum is thought to underlie this currently untreatable condition.