Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery

Boshuisen, Kim; van Schooneveld, Monique; Uiterwaal, Cuno; Cross, J.; Harrison, Sue; Polster, Tilman; Daehn, Marion; Djimjadi, Sarina; YALNIZOĞLU, DİLEK; Turanli, Guzide; Sassen, Robert; Hoppe, Christian; Kuczaty, Stefan; Barba, Carmen; Kahane, Philippe; Schubert-Bast, Susanne; Reuner, Gitta; Bast, Thomas; Strobl, Karl; Mayer, Hans; de Saint-Martin, Anne; Seegmuller, Caroline; Laurent, Agathe; Arzimanoglou, Alexis; Braun, Kees

doi:10.1002/ana.24427

Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery

Boshuisen K., van Schooneveld M. M. J., Uiterwaal C. S. P. M., Cross J. H., Harrison S., Polster T., ...Daha Fazla

ANNALS OF NEUROLOGY, cilt.78, sa.1, ss.104-114, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 78 Sayı: 1
Basım Tarihi: 2015
Doi Numarası: 10.1002/ana.24427
Dergi Adı: ANNALS OF NEUROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.104-114
Hacettepe Üniversitesi Adresli: Evet

Özet

ObjectiveAntiepileptic drugs (AEDs) have cognitive side effects that, particularly in children, may affect intellectual functioning. With the TimeToStop (TTS) study, we showed that timing of AED withdrawal does not majorly influence long-term seizure outcomes. We now aimed to evaluate the effect of AED withdrawal on postoperative intelligence quotient (IQ), and change in IQ (delta IQ) following pediatric epilepsy surgery.