Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery

Boshuisen K., van Schooneveld M. M. J., Uiterwaal C. S. P. M., Cross J. H., Harrison S., Polster T., ...More

ANNALS OF NEUROLOGY, vol.78, no.1, pp.104-114, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1002/ana.24427
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.104-114
  • Hacettepe University Affiliated: Yes


ObjectiveAntiepileptic drugs (AEDs) have cognitive side effects that, particularly in children, may affect intellectual functioning. With the TimeToStop (TTS) study, we showed that timing of AED withdrawal does not majorly influence long-term seizure outcomes. We now aimed to evaluate the effect of AED withdrawal on postoperative intelligence quotient (IQ), and change in IQ (delta IQ) following pediatric epilepsy surgery.