Rapid detection of rifampin resistance in Mycobacterium tuberculosis isolates by heteroduplex analysis and determination of rifamycin cross-resistance in rifampin-resistant isolates


Saribas Z., Kocagoz T., Alp A., Gunlap A.

JOURNAL OF CLINICAL MICROBIOLOGY, vol.41, no.2, pp.816-818, 2003 (SCI-Expanded) identifier identifier identifier

Abstract

Direct heteroduplex analysis and a universal heteroduplex generator assay were performed to detect rifampin resistance rapidly in Turkish Mycobacterium tuberculosis isolates. Cross-resistance to rifapentine, rifabutin, and rifalazil was investigated. A relationship between specific mutations and resistance patterns, which can guide the choice of an appropriate therapeutic regimen for tuberculosis patients, was identified.