A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light

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Turan I. S., Yildiz D., Turksoy A., GÜNAYDIN G., Akkaya E. U.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, cilt.55, sa.8, ss.2875-2878, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 8
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1002/anie.201511345
  • Dergi Adı: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2875-2878
  • Anahtar Kelimeler: BODIPY, peroxides, photochemistry, photodynamic therapy, singlet oxygen, BODIPY DYES, IN-VIVO, TUMOR OXYGENATION, CANCER, DERIVATIVES, PDT, PHOTOCYTOTOXICITY, ACTIVATION, PORPHYRIN, EFFICIENT
  • Hacettepe Üniversitesi Adresli: Evet

Özet

The photosensitized generation of singlet oxygen within tumor tissues during photodynamic therapy (PDT) is self-limiting, as the already low oxygen concentrations within tumors is further diminished during the process. In certain applications, to minimize photoinduced hypoxia the light is introduced intermittently (fractional PDT) to allow time for the replenishment of cellular oxygen. This condition extends the time required for effective therapy. Herein, we demonstrated that a photosensitizer with an additional 2-pyridone module for trapping singlet oxygen would be useful in fractional PDT. Thus, in the light cycle, the endoperoxide of 2-pyridone is generated along with singlet oxygen. In the dark cycle, the endoperoxide undergoes thermal cycloreversion to produce singlet oxygen, regenerating the 2-pyridone module. As a result, the photodynamic process can continue in the dark as well as in the light cycles. Cell-culture studies validated this working principle in vitro.