One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD)
THORAX, vol.75, no.2, pp.172-175, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 75 Issue: 2
- Publication Date: 2020
- Doi Number: 10.1136/thoraxjnl-2019-213217
- Journal Name: THORAX
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
- Page Numbers: pp.172-175
- Open Archive Collection: AVESIS Open Access Collection
- Hacettepe University Affiliated: Yes
Abstract
We performed a prospective, observational, cohort study of children newly diagnosed with children's interstitial lung disease (ChILD), with structured follow-up at 4, 8, 12 weeks and 6 and 12 months. 127 children, median age 0.9 (IQR 0.3-7.9) years had dyspnoea (68%, 69/102), tachypnoea (75%, 77/103) and low oxygen saturation (SpO(2)) median 92% (IQR 88-96). Death (n=20, 16%) was the most common in those <6 months of age with SpO(2)<94% and developmental/surfactant disorders. We report for the first time that ChILD survivors improved multiple clinical parameters within 8-12 weeks of diagnosis. These data can inform family discussions and support clinical trial measurements.