Akademik Veri Yönetim Sistemi
Applications of Plant Molecular Farming, Kole C,Chaurasia A,Hefferon KL,Panigrahi J, Editör, Springer Nature, Singapore, ss.295-323, 2024
Vaccines are effective tools for the prophylaxis of infectious diseases. Various diseases have been eradicated using vaccines, and the importance of vaccination has recently been comprehended well in the COVID-19 pandemic. However, access to vaccines is generally limited, especially in least developed countries. Plants have many advantages in subunit vaccine development against infectious diseases, such as safety, lower cost, and delivery of antigens to induce gut-associated mucosal immunity. Antigenic proteins can be produced in plants either stably by integrating the gene of interest into the nuclear or chloroplast genome or transiently using vectors such as viruses. Transgenic plants can produce large amounts of antigen followed by the purification of protein to be used in vaccine formulation. Additionally, antigen-expressing plants can be used in feeding as oral vaccines to induce mucosal immunity in the gut. Various plant-based vaccine candidates have been developed against many viral and bacterial diseases. Some candidates were evaluated in human clinical trials, and the plant-based COVID-19 vaccine Medicago Covifenz® was approved in Canada for human use. Progress in the derivation of vaccines from plants shows promise that plant-based vaccines will be on the agenda more often in the near future.