Expression levels of maternal plasma microRNAs in preeclamptic pregnancies

AKGÖR U., AYAZ L., Cayan F.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.41, no.6, pp.910-914, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.1080/01443615.2020.1820465
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.910-914
  • Keywords: Circulating miRNA, preeclampsia, biomarker, maternal miRNA, pregnancy complications, CIRCULATING MICRORNAS, HYPOXIA, TROPHOBLASTS, INHIBITION, PLACENTA, INVASION
  • Hacettepe University Affiliated: Yes


The present study aimed to identify the differential expression profiles of microRNAs in the plasma between patients with preeclampsia (PE) and healthy pregnancies using quantitative real-time PCR. The expression profiles of 32 miRNAs in maternal plasma from 31 patients with PE and 32 healthy pregnancies were evaluated. The expression levels of eight miRNAs including miR-210, miR-375, miR-197-3p, miR-132-3p, miR-29a-3p, miR-328, miR-24-3p, and miR-218-5p were significantly upregulated and the expression levels of three miRNAs, including miR-302b-3p, miR-191-5p, and miR-17-5p, were significantly downregulated in patients with preeclampsia when compared to healthy pregnant women. In conclusion, we identified 11 miRNAs that may be potential biomarkers for non-invasive diagnosis and a pivotal role in the prediction of PE. Considering the small cohort of patients, further studies with larger samples from different gestational stages are necessary to confirm our findings. IMPACT STATEMENT