Poly(hydroxyethyl methacrylate)-based macroporous hydrogels with disulfide cross-linker


Andac M. , Plieva F. M. , Denizli A. , Galaev I. Y. , Mattiasson B.

MACROMOLECULAR CHEMISTRY AND PHYSICS, vol.209, no.6, pp.577-584, 2008 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 209 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1002/macp.200700467
  • Title of Journal : MACROMOLECULAR CHEMISTRY AND PHYSICS
  • Page Numbers: pp.577-584

Abstract

Biodegradable supermacroporous PHEMA cryogels were produced by combining two cross-linkers, poly(ethylene glycol) diacrylate and a newly developed disulfide water soluble crosslinker, N,N'-bis(methacryloyl)-L-cystine. The biodegradable PHEMA cryogels were prepared with gel fraction yields up to 70% and were characterized by highly interconnected pores of micrometer size and good mechanical stability. When subjected to reductive agents like DTT, the biodegradable PHEMA cryogels disintegrated into small pieces. The rate of disintegration was controlled by the crosslinking density in the cryogels and the DTT concentration.