The effects of fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on lipopolysaccharide-induced airway inflammation in mice


Abohalaka R., Bozkurt T. E. , Nemutlu E., Onder S., Sahin-Erdemli I.

PULMONARY PHARMACOLOGY & THERAPEUTICS, vol.62, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62
  • Publication Date: 2020
  • Doi Number: 10.1016/j.pupt.2020.101920
  • Journal Name: PULMONARY PHARMACOLOGY & THERAPEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Keywords: Fatty acid amide hydrolase (FAAH), Monoacylglycerol lipase (MAGL), Airway, Airway hyperreactivity, Airway inflammation, Endocannabinoid, NUCLEAR FACTOR, T-CELLS, CANNABINOIDS, ANANDAMIDE, INCREASES, MODULATION, EXPRESSION, RECEPTORS, MARIJUANA, BLOCKADE
  • Hacettepe University Affiliated: Yes

Abstract

Cannabinoids and the endocannabinoid system significantly contributes to the airway inflammation. Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) are two main enzymes responsible for the metabolism of the endocannabinoids anandamide (AEA) and 2-arachydonoyl glycerol (2-AG), respectively. In the present study, we aimed to investigate the effects of local and systemic FAAH and MAGL inhibitor treatments in experimental airway inflammation and tracheal hyperreactivity in mice.