PULMONARY PHARMACOLOGY & THERAPEUTICS, vol.62, 2020 (SCI-Expanded)
Article / Article
PULMONARY PHARMACOLOGY & THERAPEUTICS
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
Fatty acid amide hydrolase (FAAH), Monoacylglycerol lipase (MAGL), Airway, Airway hyperreactivity, Airway inflammation, Endocannabinoid, NUCLEAR FACTOR, T-CELLS, CANNABINOIDS, ANANDAMIDE, INCREASES, MODULATION, EXPRESSION, RECEPTORS, MARIJUANA, BLOCKADE
Hacettepe University Affiliated:
Cannabinoids and the endocannabinoid system significantly contributes to the airway inflammation. Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) are two main enzymes responsible for the metabolism of the endocannabinoids anandamide (AEA) and 2-arachydonoyl glycerol (2-AG), respectively. In the present study, we aimed to investigate the effects of local and systemic FAAH and MAGL inhibitor treatments in experimental airway inflammation and tracheal hyperreactivity in mice.