Dopamine-modified halloysite as new anticancer drug carrier system

Tansik E., KAPLAN CAN H.

POLIMERY, vol.70, no.5, pp.322-330, 2025 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 5
  • Publication Date: 2025
  • Doi Number: 10.14314/polimery.2025.5.3
  • Journal Name: POLIMERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Central & Eastern European Academic Source (CEEAS), Compendex, Directory of Open Access Journals
  • Page Numbers: pp.322-330
  • Hacettepe University Affiliated: Yes

Abstract

A new anticancer drug carrier system based on polydopamine-functionalized halloysite (PDA-HNT) was developed. Hansen solubility parameters were used to select 5-fluorouracil (5-FU) as an anticancer drug. The obtained system was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and nuclear mag-netic resonance (1H NMR, 19F-NMR). It was shown that PDA-HNT may be a promising drug nanocarrier for delivery systems in cancer therapy.