Human Mastadenovirus A Infection in a Child During the Course of Hematopoietic Stem Cell Transplant


YALÇIN S. S., KUŞKONMAZ B. B., Perez-Brocal V., Cetinkaya D. U., Moya A., DİNLEYİCİ E. Ç.

EXPERIMENTAL AND CLINICAL TRANSPLANTATION, cilt.22, sa.9, ss.726-729, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 9
  • Basım Tarihi: 2024
  • Doi Numarası: 10.6002/ect.2022.0049
  • Dergi Adı: EXPERIMENTAL AND CLINICAL TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.726-729
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Following primary infection, human mastadeno-viruses can persist in various tissues. We report a caseof a pediatric patient with Fanconi anemia who had acomplicated posttransplant course after allogeneichematopoietic stem cell transplant that wasassociated with human mastadenovirus infection.Human mastadenovirus reactivation was detectedwith metagenomic analysis during a 3-month follow-up period; the predominant rate of occurrence ofhuman mastadenoviruses was 1.1% on day 0, 84% onday +15, 90% on day +30, and 42% on day +82. Virusshedding continued up to 3 months after transplant.At 36 months after hematopoietic stem cell transplant,the patient was in good clinical condition with fulldonor chimerism. Long-term follow-up studies forhuman mastadenoviruses are needed to determinelatency period.