Human Mastadenovirus A Infection in a Child During the Course of Hematopoietic Stem Cell Transplant
EXPERIMENTAL AND CLINICAL TRANSPLANTATION, vol.22, no.9, pp.726-729, 2024 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 22 Issue: 9
- Publication Date: 2024
- Doi Number: 10.6002/ect.2022.0049
- Journal Name: EXPERIMENTAL AND CLINICAL TRANSPLANTATION
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.726-729
- Hacettepe University Affiliated: Yes
Abstract
Following primary infection, human mastadeno-viruses can persist in various tissues. We report a caseof a pediatric patient with Fanconi anemia who had acomplicated posttransplant course after allogeneichematopoietic stem cell transplant that wasassociated with human mastadenovirus infection.Human mastadenovirus reactivation was detectedwith metagenomic analysis during a 3-month follow-up period; the predominant rate of occurrence ofhuman mastadenoviruses was 1.1% on day 0, 84% onday +15, 90% on day +30, and 42% on day +82. Virusshedding continued up to 3 months after transplant.At 36 months after hematopoietic stem cell transplant,the patient was in good clinical condition with fulldonor chimerism. Long-term follow-up studies forhuman mastadenoviruses are needed to determinelatency period.