Effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage in rats


Gulsen S., Inci S. , Yuruk S., YAŞAR Ü. , Ozgen T.

NEUROLOGIA MEDICO-CHIRURGICA, cilt.47, ss.537-542, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 47 Konu: 12
  • Basım Tarihi: 2007
  • Doi Numarası: 10.2176/nmc.47.537
  • Dergi Adı: NEUROLOGIA MEDICO-CHIRURGICA
  • Sayfa Sayıları: ss.537-542

Özet

The effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage (SAH) was investigated in a rat model. Seven groups of seven rats underwent no SAH, no treatment; SAH only; SAH plus vehicle; SAH plus 3 days intraperitoneal raloxifene treatment; SAH plus 4 days intraperitoneal raloxifene treatment; SAH plus 3 days intrathecal raloxifene treatment; and SAH plus 4 days intrathecal raloxifene treatment. The basilar artery cross-sectional areas were measured at 72 or 96 hours following SAH. The results showed raloxifene decreased SAH-induced cerebral vasospasm in all treatment groups, and suggested no difference between intraperitoneal and intrathecal application, or between 3 days and 4 days of raloxifene treatment. The present study demonstrates that raloxifene is a potential therapeutic agent against cerebral vasospasm after SAH.