Comparison of endothelin and nitric oxide synthase blockers on hemorheological parameters in endotoxemic rats

Falkmarken N. H. D., ARIHAN O., İSKİT A. B.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.3, pp.1045-1052, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1607-19
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1045-1052
  • Hacettepe University Affiliated: Yes

Abstract

Background/aim: Septic shock is an important health problem that vastly alters cardiovascular and hemodynamic status. Increased production of nitric oxide (NO) and endothelin is a counterpart of this endotoxemic state. This study was conducted to test the hypothesis that nonselective NO synthesis blocker (L-NAME), inducible NO synthesis blocker (L-canavanine), or endothelin receptor antagonist (bosentan) will reverse the effects of sepsis on hemorheological parameters.