Comparison of endothelin and nitric oxide synthase blockers on hemorheological parameters in endotoxemic rats
TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.3, pp.1045-1052, 2017 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 47 Issue: 3
- Publication Date: 2017
- Doi Number: 10.3906/sag-1607-19
- Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.1045-1052
- Hacettepe University Affiliated: Yes
Abstract
Background/aim: Septic shock is an important health problem that vastly alters cardiovascular and hemodynamic status. Increased production of nitric oxide (NO) and endothelin is a counterpart of this endotoxemic state. This study was conducted to test the hypothesis that nonselective NO synthesis blocker (L-NAME), inducible NO synthesis blocker (L-canavanine), or endothelin receptor antagonist (bosentan) will reverse the effects of sepsis on hemorheological parameters.