Inhibition of DNA Topoisomerases by a Series of Benzoxazoles and their Possible Metabolites

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ZİLİFDAR FOTO F., Foto E., Ertan-Bolelli T., YILDIZ İ., Aki-Yalcin E., DİRİL N.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.15, no.11, pp.1155-1162, 2018 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 15 Issue: 11
• Publication Date: 2018
• Doi Number: 10.2174/1570180815666180124143246
• Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1155-1162
• Hacettepe University Affiliated: Yes

Abstract

Background: A series of 2-substituted benzoxazoles and their possible metabolites, N-(2-hydroxy-4(or 5)-nitrophenyl)benzamides and phenylacetamides, which were previously synthesized by our group, were investigated for their inhibitory activities on both eukaryotic DNA topoisomerase I (Topo I) and II (Topo II).