Inhibition of DNA Topoisomerases by a Series of Benzoxazoles and their Possible Metabolites


ZİLİFDAR FOTO F. , Foto E., Ertan-Bolelli T., YILDIZ İ., Aki-Yalcin E., DİRİL N.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.15, no.11, pp.1155-1162, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 11
  • Publication Date: 2018
  • Doi Number: 10.2174/1570180815666180124143246
  • Title of Journal : LETTERS IN DRUG DESIGN & DISCOVERY
  • Page Numbers: pp.1155-1162

Abstract

Background: A series of 2-substituted benzoxazoles and their possible metabolites, N-(2-hydroxy-4(or 5)-nitrophenyl)benzamides and phenylacetamides, which were previously synthesized by our group, were investigated for their inhibitory activities on both eukaryotic DNA topoisomerase I (Topo I) and II (Topo II).