Inhibition of DNA Topoisomerases by a Series of Benzoxazoles and their Possible Metabolites


ZİLİFDAR FOTO F. , Foto E., Ertan-Bolelli T., YILDIZ İ., Aki-Yalcin E., DİRİL N.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.15, sa.11, ss.1155-1162, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Konu: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1570180815666180124143246
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Sayfa Sayıları: ss.1155-1162

Özet

Background: A series of 2-substituted benzoxazoles and their possible metabolites, N-(2-hydroxy-4(or 5)-nitrophenyl)benzamides and phenylacetamides, which were previously synthesized by our group, were investigated for their inhibitory activities on both eukaryotic DNA topoisomerase I (Topo I) and II (Topo II).