The structure of 1-(p-fluorophenylmethyl)-2-(4-methyl-1-piperazinyl)-1H-benzimidazole hydrogen fumarate


Ozbey S. , KENDI E., GOKER H. , TUNCBILEK M. G.

JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, cilt.28, sa.6, ss.461-464, 1998 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Konu: 6
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1023/a:1021720706126
  • Dergi Adı: JOURNAL OF CHEMICAL CRYSTALLOGRAPHY
  • Sayfa Sayıları: ss.461-464

Özet

The crystal and molecular structure of the title compound has been determined by X-ray analysis. The 1-(p-fluorophenylmethyl)-2-(4-methyl-1-piperazinyl)-1H-benzimidazole ion cocrystallizes with fumaric acid, (C19H22N4F+. C4H3O4-), in space group P-1 with cell dimensions a = 9.938(1), b = 10.131(1), c = 12.712(1) Angstrom, alpha = 86.57(1), beta = 69.41(2), and gamma = 67.22(2)degrees. The piperazine N4 atom is protonated and contacts the deprotonated O atom of the fumarate anion through a hydrogen bond. The benzimidazole ring is nearly planar and makes a dihedral angle of 111.25(12)degrees with the fluorophenyl ring. The piperazine ring adopts a chair conformation.