Akademik Veri Yönetim Sistemi
PEDIATRIC ALLERGY AND IMMUNOLOGY, cilt.32, sa.1, ss.146-152, 2021 (SCI-Expanded)
Background Chronic inducible urticaria (CIndU) is a subtype of chronic urticaria induced by a physical stimulus. Objective To evaluate the clinical features, prognostic factors, and natural course of childhood CIndU subtypes. Methods Patients (1-18 years old, n = 117) diagnosed with CIndU between March 2011 and March 2019 were analyzed. Patients (n = 101) were re-evaluated for the status of their CIndU at least 6 months after the initial evaluation. Results The study population comprised of 117 children with a median (inter-quartile range) age of 10.3 (6-14.8) years at admission and a male predominance (53%). Symptomatic dermographism was the most common type of CIndU, affecting 65% of the group, followed by cold urticaria and cholinergic urticaria, which affected 17% and 15.4%, respectively. Baseline serum tryptase levels in cholinergic urticaria and cold urticaria were higher than those in symptomatic dermographism [7.0 (3.3-10.7) mu g/L, 4.2 (2.8-9.3) mu g/L, and 2.7 mu g/L (1.8-5.9), respectively;P = .020]. Recovery was observed in 9.6%, 25.3%, and 34.7% of the CIndU children after 12, 36, and 60 months, respectively. Of the patients with symptomatic dermographism, 40% had remission in 5 years, whereas this rate was only one-fifth in patients with cold urticaria. The worst prognosis was observed in patients with cholinergic urticaria. Conclusion This study concluded that nearly one-third of children with CIndU recovered within 5 years and symptomatic dermographism has the best prognosis. Cholinergic urticaria is the CIndU type with the worst prognosis, male dominance, and highest baseline serum tryptase levels.