Leflunomide prevents vasospasm secondary to subarachnoid haemorrhage

Belen D., Besalti O., Yigitkanli K., Koesemehmetoglu K., Simsek S., Bolay H.

ACTA NEUROCHIRURGICA, vol.149, no.10, pp.1041-1047, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 149 Issue: 10
  • Publication Date: 2007
  • Doi Number: 10.1007/s00701-007-1275-1
  • Journal Name: ACTA NEUROCHIRURGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1041-1047
  • Hacettepe University Affiliated: Yes

Abstract

Background. Though cerebral vasospasm is one of the most serious complications of subarachnoid haemorrhage (SAH), its complex pathogenesis is poorly understood and available clinical treatment options are unsatisfactory. This study was designed to examine the efficacy of leflunomide, an immunomodulatory agent with inhibitory properties, on vascular smooth muscle cell proliferation and inflammation in a rabbit cerebral vasospasm model.