Effects of molecular weight and ratio of guluronic acid to mannuronic acid on the antioxidant properties of sodium alginate fractions prepared by radiation-induced degradation

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Sen M.

APPLIED RADIATION AND ISOTOPES, vol.69, pp.126-129, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69
  • Publication Date: 2011
  • Doi Number: 10.1016/j.apradiso.2010.08.017
  • Journal Name: APPLIED RADIATION AND ISOTOPES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.126-129
  • Keywords: Radiation induced degradation, Sodium alginate, Antioxidant properties, IN-VITRO, CHITOSAN, POLYSACCHARIDES, IRRADIATION, DERIVATIVES, CARRAGEENAN, PLANTS, MODEL
  • Hacettepe University Affiliated: Yes

Abstract

In this study, the effects of the molecular weight and ratio of guluronic acid (G) to mannuronic acid (M), G/M, of some sodium alginate (NaAlg) fractions on their antioxidative properties were investigated. Low-molecular-weight-fractions with various G/M were prepared by gamma radiation-induced degradation of NaAlg. Change in their molecular weight was monitored. Antioxidant properties of the fractions with various molecular weight and G/M were evaluated by determining the scavenging ability of 1,1-diphenyl-2-picrylhydrazyl free radical (DPPHradical dot). 50% inhibition concentrations of the 50 kGy-irradiated NaAlgs having molecular weights of 20.5, 17.7, and 16.0 kDa were found to be 11.0, 18.0, and 24.0 mg/ml, respectively, whereas the fractions of the same molecular weight with a lower G/M exhibited a better DPPHradical dot scavenging activity. The results demonstrated that its molecular weight and G/M were important factors in controlling the antioxidant properties of NaAlg.

In this study the effects of the molecular weight and ratio of guluronic acid (G) to mannuronic acid (M) G/M of some sodium alginate (NaAlg) fractions on their antioxidative properties were investigated Low-molecular-weight-fractions with various G/M were prepared by gamma radiation-induced degradation of NaAlg Change in their molecular weight was monitored Antioxidant properties of the fractions with various molecular weight and G/M were evaluated by determining the scavenging ability of 1 1-diphenyl-2-picrylhydrazyl free radical (DPPH) 50% inhibition concentrations of the 50 kGy-irradiated NaAlgs having molecular weights of 20 5 17 7 and 16 0 kDa were found to be 11 0 18 0 and 24 0 mg/ml respectively whereas the fractions of the same molecular weight with a lower G/M exhibited a better DPPH scavenging activity The results demonstrated that its molecular weight and G/M were Important factors in controlling the antioxidant properties of NaAlg (C) 2010 Elsevier Ltd All rights reserved