Serum Levels of Annexin A2 as a Candidate Biomarker for Hepatic Fibrosis in Patients With Chronic Hepatitis B

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Kolgelier S., Demir N. A., İNKAYA A. Ç., Sumer S., OZCIMEN S., Demir L. S., ...More

HEPATITIS MONTHLY, vol.15, no.10, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 10
  • Publication Date: 2015
  • Doi Number: 10.5812/hepatmon.30655
  • Journal Name: HEPATITIS MONTHLY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Annexin A2, Hepatitis B, Chronic, Liver Fibrosis, Biological Marker, HEPATOCELLULAR-CARCINOMA, NATURAL-HISTORY, VIRUS INFECTION, LIVER FIBROSIS, EXPRESSION, MARKER
  • Hacettepe University Affiliated: Yes

Abstract

Background: Hepatologists have studied serologic markers of liver injury for decades. Annexins are a prominent group of such markers and annexin A2 (AnxA2) is one of the best characterized annexins. AnxA2 inhibits HBV polymerase among other functions. Its expression is up-regulated in regenerative hepatocytes.