Caffeic Acid Phenethyl Ester: Its Protective Role Against Certain Major Eye Diseases
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, cilt.30, sa.9, ss.700-708, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 30 Sayı: 9
- Basım Tarihi: 2014
- Doi Numarası: 10.1089/jop.2014.0046
- Dergi Adı: JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.700-708
- Hacettepe Üniversitesi Adresli: Evet
Özet
As an effective compound found mainly in the honeybee product propolis, caffeic acid phenethyl ester (CAPE) has been commonly utilized as a medicine and remedial agent, in a number of countries. Specifically, it might inhibit nuclear factor kappa B at micromolar concentrations and demonstrate antioxidant, antineoplastic, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and anti-inflammatory features. This review article summarizes the recent progress regarding the favorable effects of CAPE on a number of eye disease models, including cataract and posterior capsule opacification, corneal diseases, retina and optic nerve-related diseases, ischemia/reperfusion injury of retina, inflammation and infection-related diseases. CAPE has been found to exhibit promising efficacy, with minimal adverse effects, in animal and cell culture studies of several eye diseases.