Embolization with polyhydroxybutyrate (PHB) microspheres: In-vivo studies

KASSAB, AC; PISKIN, E; BILGIC, S; Denkbas, EMİR; XU, K

doi:10.1177/088391159901400401

Embolization with polyhydroxybutyrate (PHB) microspheres: In-vivo studies

KASSAB A., PISKIN E., BILGIC S., Denkbas E. B., XU K.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, cilt.14, sa.4, ss.291-303, 1999 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 14 Sayı: 4
Basım Tarihi: 1999
Doi Numarası: 10.1177/088391159901400401
Dergi Adı: JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.291-303
Hacettepe Üniversitesi Adresli: Evet

Özet

In this study polyhydroxybutyrate (PHB), produced by a methanol-utilizing bacteria, was used to prepare microspheres in the 120-200 mu m size range for embolization. A solvent evaporation technique was utilized to obtain microspheres in which methylene chloride, distilled water and polyvinyl alcohol were used as the solvent, precipitation medium and emulsifier, respectively. Dogs were the test animals. Renal angiograms obtained before and after embolization and also the histopathological observations showed the feasibility of using these microspheres as an alternative embolization/chemoembolization agent.