Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles


Cicek O. S. Y. , HEKİMOĞLU E. R. , TURĞAL M., ATİLLA P., ÇAKAR A. N. , USUBÜTÜN A., ...More

PLACENTA, vol.69, pp.64-70, 2018 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69
  • Publication Date: 2018
  • Doi Number: 10.1016/j.placenta.2018.07.002
  • Journal Name: PLACENTA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.64-70
  • Keywords: Hydatidiform mole, Leukemia inhibitory factor (LIF), Insulin like growth factor-1 (IGF-1), Decidua, Trophoblast, Immunohistochemistry, HUMAN-PLACENTA, TROPHOBLAST INVASION, FACTOR LIF, FETOMATERNAL INTERFACE, CHORIOCARCINOMA CELLS, HUMAN ENDOMETRIUM, BINDING, IGF, RECEPTOR, BIOSYNTHESIS

Abstract

Introduction: Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding of the proliferative processes in HMs.