Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles

Cicek, Ozge; HEKİMOĞLU, EMİNE; TURĞAL, MERT; ATİLLA, PERGİN; ÇAKAR, AYŞE; USUBÜTÜN, ALP; BEKSAÇ, MEHMET

doi:10.1016/j.placenta.2018.07.002

Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles

Cicek O. S. Y., HEKİMOĞLU E. R., TURĞAL M., ATİLLA P., ÇAKAR A. N., USUBÜTÜN A., ...Daha Fazla

PLACENTA, cilt.69, ss.64-70, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 69
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.placenta.2018.07.002
Dergi Adı: PLACENTA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.64-70
Anahtar Kelimeler: Hydatidiform mole, Leukemia inhibitory factor (LIF), Insulin like growth factor-1 (IGF-1), Decidua, Trophoblast, Immunohistochemistry, HUMAN-PLACENTA, TROPHOBLAST INVASION, FACTOR LIF, FETOMATERNAL INTERFACE, CHORIOCARCINOMA CELLS, HUMAN ENDOMETRIUM, BINDING, IGF, RECEPTOR, BIOSYNTHESIS
Hacettepe Üniversitesi Adresli: Evet

Özet

Introduction: Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding of the proliferative processes in HMs.