The Effects of Desferroxamine on Bone and Bone Graft Healing in Critical-Size Bone Defects


Guzey S., Aykan A., Ozturk S., Avsever H., Karslioglu Y., Ertan A. A.

ANNALS OF PLASTIC SURGERY, vol.77, no.5, pp.560-568, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1097/sap.0000000000000679
  • Journal Name: ANNALS OF PLASTIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.560-568
  • Hacettepe University Affiliated: Yes

Abstract

Background: Autogenous bone grafts are still the criterion standard treatment option in critical-size bone defect reconstructions, and many therapies can affect its incorporation. In this study, it was aimed to research the effects of desferroxamine (DFO) application on bone and bone graft healing due to the effects of osteoblast and osteoclast regulation and stimulation of angiogenesis.