Meningioma-like inflammatory myofibroblastic tumor of the lung with TPM3::ALK fusion

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Akın A. E., DURMAZ ÖZDİNÇ C. D., Yılmaz A. N., AKÇİN Ö. Ç., KURTULAN O., ÖNDER B. Ş., ...More

Virchows Archiv, 2026 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2026
  • Doi Number: 10.1007/s00428-026-04451-z
  • Journal Name: Virchows Archiv
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE
  • Keywords: Inflammatory myofibroblastic tumor, Meningioma, TPM3::ALK fusion
  • Hacettepe University Affiliated: Yes

Abstract

Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor characterized by spindle cells with myofibroblastic differentiation, accompanying chronic inflammatory cells, and the hallmark genetic signature of mainly ALK or ROS1 rearrangements. Here, we report a lung IMT in a 45-year-old female demonstrating a unique meningothelial-like pattern, equivocal ALK expression (negative for clone 5A4 and positive for clone ALK1), negative ALK rearrangement by FISH, and the presence of the TPM3::ALK fusion. To our knowledge, this is the first reported case of lung IMT displaying meningothelial-like whorls, with a particular focus on differential diagnosis.