Meningioma-like inflammatory myofibroblastic tumor of the lung with TPM3::ALK fusion
Virchows Archiv, vol.489, no.1, pp.233-237, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 489 Issue: 1
- Publication Date: 2026
- Doi Number: 10.1007/s00428-026-04451-z
- Journal Name: Virchows Archiv
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE
- Page Numbers: pp.233-237
- Keywords: Inflammatory myofibroblastic tumor, Meningioma, TPM3::ALK fusion
- Hacettepe University Affiliated: Yes
Abstract
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor characterized by spindle cells with myofibroblastic differentiation, accompanying chronic inflammatory cells, and the hallmark genetic signature of mainly ALK or ROS1 rearrangements. Here, we report a lung IMT in a 45-year-old female demonstrating a unique meningothelial-like pattern, equivocal ALK expression (negative for clone 5A4 and positive for clone ALK1), negative ALK rearrangement by FISH, and the presence of the TPM3::ALK fusion. To our knowledge, this is the first reported case of lung IMT displaying meningothelial-like whorls, with a particular focus on differential diagnosis.