Akademik Veri Yönetim Sistemi
JOURNAL OF CONTEMPORARY BRACHYTHERAPY, sa.2, ss.132-138, 2024 (SCI-Expanded)
Purpose: To compare the dosimetric performance of vaginal intensity -modulated brachytherapy (IM-BRT) applicator and single- (SC-BRT) and multi -channel brachytherapy (MC-BRT) applicators for vaginal cuff brachytherapy (VC-BRT). Material and methods: Fifteen patients with uterine -confined endometrium cancer who received adjuvant VC-BRT were included in this study. IM-BRT, SC-BRT, and MC-BRT treatment plans were created for two different clinical target volume (CTV) definitions: 1. Standard CTV, called CTVs; and 2. Virtually defined CTV, called CTVv, with asym - metrical tumor extension > 5 mm in thickness. Plan comparison was performed using dose -volume histogram (DVH) and treatment planning parameters. Results: According to DVH analysis, D 98 for CTVv and D 2 for both CTVs and CTVv showed statistically significant differences between IM-BRT and SC-BRT plans, but there was no significant difference between IM-BRT and MC-BRT plans in terms of D 98 and D 2 for both CTVs and CTVv. Additionally, for CTVv plans, IM-BRT was found to be signifi - cantly superior to SC-BRT for the rectum (D 2cc , V 5Gy , and V 7Gy ), bladder (D 2cc and V 7Gy ), and small bowel (D 2cc , V 5Gy , and V 7Gy ). On the other hand, DVH parameters of the sigmoid showed large difference between IM-BRT and SC-BRT plans, but it was not statistically significant. Similarly, the use of IM-BRT applicator demonstrated a noticeable dose reduction in all defined OARs when compared with MC-BRT applicator, but statistically significant for the rectum V 7Gy ( p = 0.03) only. Conclusions: While the IM-BRT applicator is still in pre -clinical phase, our investigation demonstrated the proofof -concept in real patient treatment plans with promising dosimetric results compared with SC-BRT and MC-BRT plans in selected patient group.