Ureterovesical junction obstruction causes increment in smooth muscle contractility, and cholinergic and adrenergic activity in distal ureter of rabbits

Yalcin, Sule; Ertunc, AHMET; ARDIÇLI, BURAK; Kabakus, Ismail; Tas, Taskin; Sara, MEHMET; Onur, Rustu; KARNAK, İBRAHİM

doi:10.1016/j.jpedsurg.2013.01.030

Ureterovesical junction obstruction causes increment in smooth muscle contractility, and cholinergic and adrenergic activity in distal ureter of rabbits

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Yalcin S., Ertunc M., ARDIÇLI B., Kabakus I. M., Tas T. S., Sara Y., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.48, no.9, pp.1954-1961, 2013 (SCI-Expanded)

Publication Type: Article / Article
Volume: 48 Issue: 9
Publication Date: 2013
Doi Number: 10.1016/j.jpedsurg.2013.01.030
Journal Name: JOURNAL OF PEDIATRIC SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1954-1961
Keywords: Ureterovesical junction, Obstruction, Contractility, Distal ureter, UPPER URINARY-TRACT, CAJAL-LIKE CELLS, RENIN-ANGIOTENSIN SYSTEM, WHOLE-MOUNT PREPARATION, GENE-RELATED PEPTIDE, PRIMARY MEGAURETER, GUINEA-PIG, PYELOURETERAL MOTILITY, INTRAMURAL INNERVATION, ADRENOCEPTOR SUBTYPES
Hacettepe University Affiliated: Yes

Abstract

Background/Purpose: The controversy in management of primary obstructed megaureter necessitates further elucidation of the underlying pathophysiology. We evaluated smooth muscle contractility, and cholinergic, adrenergic and serotonergic activity of rabbit distal ureters after ureterovesical junction (UVJ) obstruction.