Pregnancy outcomes of the patients with anti-smooth muscle antibody positivity


Ünal C., FADILOĞLU E., Beksac M. S.

Human Antibodies, vol.27, no.3, pp.167-170, 2019 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.3233/hab-190365
  • Journal Name: Human Antibodies
  • Journal Indexes: Scopus
  • Page Numbers: pp.167-170
  • Keywords: Anti-smooth muscle antibody, autoantibodies, autoimmunity, high risk pregnancy
  • Hacettepe University Affiliated: Yes

Abstract

BACKROUND AND AIMS: To evaluate the management and the pregnancy outcomes of patients positive for anti-smooth muscle antibody (ASMA). METHODS: We retrospectively evaluated the pregnancy outcomes of the patients with ASMA positivity compared to patients without any known autoantibody positivity and/or autoimmune diseases. We have also evaluated the obstetric outcomes of the patients with ASMA positivity in terms of existence of MTHFR polymorphisms, other hereditery thrombophilias and other autoantibody positivities. RESULS: In this study, 40 ASMA positive patient were evaluated and compared with 80 control cases. Gestational week at delivery, birthweight and APGAR scores for the 1st, 5th, 10th were significantly lower at patients with ASMA positivity (p< 0.01; p< 0.01; p< 0.01; p< 0.01; p: 0.030 respectively). Further analysis regarding to existence of additional risk factors revealed no significant difference between each pair of groups in terms of any obstetric outcome. CONCLUSIONS: ASMA positivity may be associated with adverse pregnancy outcomes.