The effect of CD14-C159T genotypes on the cytokine response to endotoxin by peripheral blood mononuclear cells from asthmatic children

Keskin O., Birben E., Sackesen C., Soyer O. U., Alyamac E., Karaaslan C., ...More

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, vol.97, no.3, pp.321-328, 2006 (SCI-Expanded) identifier identifier


Background: A C-T polymorphism at position 159 in the promoter of CD14 (C-159T) modulates the cellular response to endotoxin and significantly influences total IgE levels. The effect of this genetic variant on the cytokine response of the inflammatory cells is incompletely understood.