Platelet Toll-like receptor and its ligand HMGB-1 expression is increased in the left atrium of atrial fibrillation patients


Gurses K. M. , Kocyigit D., Yalcin M. U. , CANPINAR H., EVRANOS B., CANPOLAT U., ...More

CYTOKINE, vol.103, pp.50-56, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 103
  • Publication Date: 2018
  • Doi Number: 10.1016/j.cyto.2017.12.007
  • Journal Name: CYTOKINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.50-56
  • Keywords: Atrial fibrillation, Toll-like receptor, Immunity, Platelets, Thrombosis, VON-WILLEBRAND-FACTOR, THROMBUS FORMATION, MARKERS, PROTEIN, COAGULATION, ENDOCARDIUM, ACTIVATION, TLR2, INFLAMMATION, DYSFUNCTION
  • Hacettepe University Affiliated: Yes

Abstract

Background: Atrial fibrillation(AF) is the most common sustained arrhythmia. Its most feared sequelae are stroke and peripheral thromboembolism due to atrial thrombi formation. Mechanisms underlying the relationship between platelet activation and left atrial thrombi have not been clearly elucidated yet. We aimed to investigate whether immune-mediated platelet activation occurred in AF patients in this cross-sectional study.