Platelet Toll-like receptor and its ligand HMGB-1 expression is increased in the left atrium of atrial fibrillation patients

Gurses K. M., Kocyigit D., Yalcin M. U., CANPINAR H., EVRANOS B., CANPOLAT U., ...Daha Fazla

CYTOKINE, cilt.103, ss.50-56, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 103
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.cyto.2017.12.007
  • Dergi Adı: CYTOKINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.50-56
  • Anahtar Kelimeler: Atrial fibrillation, Toll-like receptor, Immunity, Platelets, Thrombosis, VON-WILLEBRAND-FACTOR, THROMBUS FORMATION, MARKERS, PROTEIN, COAGULATION, ENDOCARDIUM, ACTIVATION, TLR2, INFLAMMATION, DYSFUNCTION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Atrial fibrillation(AF) is the most common sustained arrhythmia. Its most feared sequelae are stroke and peripheral thromboembolism due to atrial thrombi formation. Mechanisms underlying the relationship between platelet activation and left atrial thrombi have not been clearly elucidated yet. We aimed to investigate whether immune-mediated platelet activation occurred in AF patients in this cross-sectional study.