Platelet Toll-like receptor and its ligand HMGB-1 expression is increased in the left atrium of atrial fibrillation patients

Gurses, Kadri; Kocyigit, DUYGU; Yalcin, Muhammed; CANPINAR, HANDE; EVRANOS, BANU; CANPOLAT, UĞUR; YORGUN, HİKMET; Sahiner, Levent; Guc, DİCLE; AYTEMİR, KUDRET

doi:10.1016/j.cyto.2017.12.007

Platelet Toll-like receptor and its ligand HMGB-1 expression is increased in the left atrium of atrial fibrillation patients

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Gurses K. M., Kocyigit D., Yalcin M. U., CANPINAR H., EVRANOS B., CANPOLAT U., ...More

CYTOKINE, vol.103, pp.50-56, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 103
Publication Date: 2018
Doi Number: 10.1016/j.cyto.2017.12.007
Journal Name: CYTOKINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.50-56
Keywords: Atrial fibrillation, Toll-like receptor, Immunity, Platelets, Thrombosis, VON-WILLEBRAND-FACTOR, THROMBUS FORMATION, MARKERS, PROTEIN, COAGULATION, ENDOCARDIUM, ACTIVATION, TLR2, INFLAMMATION, DYSFUNCTION
Hacettepe University Affiliated: Yes

Abstract

Background: Atrial fibrillation(AF) is the most common sustained arrhythmia. Its most feared sequelae are stroke and peripheral thromboembolism due to atrial thrombi formation. Mechanisms underlying the relationship between platelet activation and left atrial thrombi have not been clearly elucidated yet. We aimed to investigate whether immune-mediated platelet activation occurred in AF patients in this cross-sectional study.