Poly(HEMA)/Cyclodextrin-Based Hydrogels for Subconjunctival Delivery of Cyclosporin A


Basbag A. B., GÜMÜŞDERELİOĞLU M., Simsek M., GÜNER A.

JOURNAL OF APPLIED POLYMER SCIENCE, vol.131, no.12, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 131 Issue: 12
  • Publication Date: 2014
  • Doi Number: 10.1002/app.40397
  • Journal Name: JOURNAL OF APPLIED POLYMER SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Hacettepe University Affiliated: Yes

Abstract

To enhance the solubility and ocular permeability of immunosuppressive agent, cyclosporine A (CsA), three types of delivery systems were prepared using (2-hydroxypropyl)--cyclodextrin (HPCD), and 2-hydroxyethyl methacrylate (HEMA). Those systems are (i) hydrogels of HPCD with crosslinking agent ethylene glycol diglycidylether, (ii) poly(HEMA) hydrogels, and (iii) different amounts of HPCD-containing poly(HEMA) hydrogels indicated as poly(HEMA-co-HPCD). In the presence of HEMA, hydrogels have desired mechanical integrity with lower equilibrium content than that of hydrogels without HEMA. CsA was loaded into the HPCD-based hydrogels by embedding from its aqueous suspensions in higher amounts than that of the poly(HEMA) hydrogels that were loaded by CsA-HPCD complex solution. Although the poly(HEMA) hydrogels are releasing total CsA in 3 days, long-term release was realized from HPCD-based hydrogels. For subconjunctival administration, regarding to the amounts of loaded CsA, release profiles, and mechanical integrity, the most suitable system is poly(HEMA-co-HPCD) hydrogels in high HPCD content. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40397.