Objective: In this study, it was aimed to evaluate the Turkish validity and reliability of the Cancer Stigma Scale (CASS) in women who applied for cancer screening. Methods: After the translation and cultural adaptation phase of CASS was completed, the Turkish version (T-CASS) was applied to 500 women who applied for cancer screening between December 2, 2019 and January 26, 2020, by face-to-face interview technique. The reliability of T-CASS was evaluated with internal consistency analysis and test-retest analysis. Cronbach Alpha internal consistency coefficient was calculated to evaluate internal consistency. The validity of the T-CASS was evaluated by content validity (according to the Davis technique) and construct validity. The accuracy of the six sub-dimensional structures was tested with first and second level Confirmatory Factor Analysis (CFA). Results: Cronbach’s alpha coefficient for the T-CASS was 0.659. Test-retest total scores of the T-CASS showed “moderate” correlation (r=0.488, p<0.001). The content validity results showed that all items were suitable for language validity according to the Davis Technique. According to the results of first and second order CFA, fit indices demonstrated a very good model fit. Conclusion: It was concluded that T-CASS is a “valid” and “moderately reliable” scale that can be used to measure cancer stigma in groups of women with similar sociodemographic characteristics.