Effect of modulator therapies on nutritional risk index in adults with cystic fibrosis

Akman Ar E. D., Yalçın N., Demirkan S. K., Damadoğlu E., Kalyoncu A. F.

The European Society for Clinical Nutrition and Metabolism, Milan, Italy, 7 - 10 September 2024, pp.1196, (Summary Text)

  • Publication Type: Conference Paper / Summary Text
  • Doi Number: 10.1016/j.clnesp.2024.07.691
  • City: Milan
  • Country: Italy
  • Page Numbers: pp.1196
  • Hacettepe University Affiliated: Yes

Abstract

Rationale: It is known that modulator therapies cause weight gain in patients. We aimed to compare the nutritional risk index (NRI) in adults with cystic fibrosis (CF) receiving modulator (MT) and conventional therapies (CT).
Methods: This was a prospective cohort study conducted between June-December, 2023. The NRI was calculated for all patients as: [15.19 × serum albumin (g/dL)] + [41.7 x current body weight (kg)/ideal body weight (kg)] at baseline and after 12 weeks. Patients were grouped according to NRI categories of malnourishment; non-malnourished (>100), mild (97.6-100), moderate (83.5-97.5), severe malnourishment (< 83.5).
Results: A total of 107 patients were included [mean (SD) age: 23.85 (4.98) years, 54.7% male, 46.7% MT]. In MT, mean (SD) weight (kg) and albumin (g/dL) significantly increased [54.65 (13.05) vs. 57.74 (12.85) and 4.08 (0.44) vs. 4.25 (0.39), respectively; p<0.001). On the contrary, in CT, mean (SD) weight (kg) and albumin (g/dL) significantly decreased [57.97 (10.62) vs. 56.98 (11.28) and 4.26 (0.48) vs. 4.13 (0.60), respectively; p<0.001). In baseline, mean rank NRI in CT significantly higher than in MT (59.66 vs. 47.55; p=0.044). In contrast, after 12 weeks, mean rank NRI in MT non-significantly higher than in CT (58.67 vs. 49.90; p=0.145). In MT, While the NRI category improved in 22 patients, worsened in 3 patients (p<0.001). In CT, while the NRI category improved in 2 patients, worsened in 10 patients (p<0.001).
Conclusion: To the best of our knowledge, this is the first study on positive effect of MT on NRI based on weight gain and albumin. Personalized nutrition and routine follow-up of adults with CF based on NRI is recommended prior to initiation of MT.