A co-stimulatory trap set by myeloid leukemia cells
ONCOIMMUNOLOGY, cilt.2, sa.6, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Editöre Mektup
- Cilt numarası: 2 Sayı: 6
- Basım Tarihi: 2013
- Doi Numarası: 10.4161/onci.24524
- Dergi Adı: ONCOIMMUNOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: cancer, co-stimulation, ICOS, immune evasion, PD1, EXPRESSION, MOLECULES, RESPONSES, LIGANDS
- Hacettepe Üniversitesi Adresli: Evet
Özet
The straightforward notion that tumor cells always exert immunosuppressive functions has been contradicted by the finding that myeloid leukemia cells can express potent co-stimulatory molecules. Indeed, the co-stimulatory support offered by leukemia cells can provoke helper T-cell responses. Unfavorably, this interaction allows leukemia cells to acquire immunosuppressive capacities.