A co-stimulatory trap set by myeloid leukemia cells

Esendagli G.

ONCOIMMUNOLOGY, cilt.2, sa.6, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 2 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.4161/onci.24524
  • Dergi Adı: ONCOIMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: cancer, co-stimulation, ICOS, immune evasion, PD1, EXPRESSION, MOLECULES, RESPONSES, LIGANDS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

The straightforward notion that tumor cells always exert immunosuppressive functions has been contradicted by the finding that myeloid leukemia cells can express potent co-stimulatory molecules. Indeed, the co-stimulatory support offered by leukemia cells can provoke helper T-cell responses. Unfavorably, this interaction allows leukemia cells to acquire immunosuppressive capacities.