A co-stimulatory trap set by myeloid leukemia cells
ONCOIMMUNOLOGY, vol.2, no.6, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Editorial Material
- Volume: 2 Issue: 6
- Publication Date: 2013
- Doi Number: 10.4161/onci.24524
- Journal Name: ONCOIMMUNOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Keywords: cancer, co-stimulation, ICOS, immune evasion, PD1, EXPRESSION, MOLECULES, RESPONSES, LIGANDS
- Hacettepe University Affiliated: Yes
Abstract
The straightforward notion that tumor cells always exert immunosuppressive functions has been contradicted by the finding that myeloid leukemia cells can express potent co-stimulatory molecules. Indeed, the co-stimulatory support offered by leukemia cells can provoke helper T-cell responses. Unfavorably, this interaction allows leukemia cells to acquire immunosuppressive capacities.