A co-stimulatory trap set by myeloid leukemia cells

Esendagli G.

ONCOIMMUNOLOGY, vol.2, no.6, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 2 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.4161/onci.24524
  • Journal Name: ONCOIMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: cancer, co-stimulation, ICOS, immune evasion, PD1, EXPRESSION, MOLECULES, RESPONSES, LIGANDS
  • Hacettepe University Affiliated: Yes

Abstract

The straightforward notion that tumor cells always exert immunosuppressive functions has been contradicted by the finding that myeloid leukemia cells can express potent co-stimulatory molecules. Indeed, the co-stimulatory support offered by leukemia cells can provoke helper T-cell responses. Unfavorably, this interaction allows leukemia cells to acquire immunosuppressive capacities.