M2-muscarinic acetylcholine receptor autoantibody levels predict left atrial fibrosis severity in paroxysmal lone atrial fibrillation patients undergoing cryoablation

Gurses K. M. , Yalcin M. U. , Kocyigit D., Kesikli S. A. , Canpolat U., YORGUN H., ...More

EUROPACE, vol.17, no.2, pp.239-246, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1093/europace/euu228
  • Journal Name: EUROPACE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.239-246
  • Keywords: Atrial fibrillation, Cryoablation, M2-muscarinic receptor autoantibodies, Atrial fibrosis, DELAYED ENHANCEMENT MRI, CATHETER ABLATION, MUSCARINIC RECEPTORS, ASSOCIATION, MANAGEMENT, FAILURE, TRIAL
  • Hacettepe University Affiliated: Yes


Aims Atrial fibrosis has been found to be associated with recurrent atrial fibrillation (AF) following catheter ablation. Autoantibodies against M2-muscarinic receptors (anti-M2-R) may play a role in the development of AF by inducing left atrial (LA) fibrosis. In this study, we aim to compare anti-M2-R levels between paroxysmal lone AF patients and healthy control subjects and to investigate the relationship between pre-ablation anti-M2-R level, LA fibrosis quantified by delayed enhancement magnetic resonance imaging (DE-MRI), and AF recurrence following cryoablation.