M2-muscarinic acetylcholine receptor autoantibody levels predict left atrial fibrosis severity in paroxysmal lone atrial fibrillation patients undergoing cryoablation

Gurses, KADRİ; Yalcin, MUHAMMED; Kocyigit, DUYGU; Kesikli, SACİT; Canpolat, UĞUR; YORGUN, HİKMET; ŞAHİNER, MEHMET; KAYA, ERGÜN; HAZIROLAN, TUNCAY; ÖZER, NECLA; Oto, Mehmet; Guc, Dicle; Aytemir, Kudret

doi:10.1093/europace/euu228

M2-muscarinic acetylcholine receptor autoantibody levels predict left atrial fibrosis severity in paroxysmal lone atrial fibrillation patients undergoing cryoablation

Gurses K. M., Yalcin M. U., Kocyigit D., Kesikli S. A., Canpolat U., YORGUN H., ...Daha Fazla

EUROPACE, cilt.17, sa.2, ss.239-246, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 17 Sayı: 2
Basım Tarihi: 2015
Doi Numarası: 10.1093/europace/euu228
Dergi Adı: EUROPACE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.239-246
Anahtar Kelimeler: Atrial fibrillation, Cryoablation, M2-muscarinic receptor autoantibodies, Atrial fibrosis, DELAYED ENHANCEMENT MRI, CATHETER ABLATION, MUSCARINIC RECEPTORS, ASSOCIATION, MANAGEMENT, FAILURE, TRIAL
Hacettepe Üniversitesi Adresli: Evet

Özet

Aims Atrial fibrosis has been found to be associated with recurrent atrial fibrillation (AF) following catheter ablation. Autoantibodies against M2-muscarinic receptors (anti-M2-R) may play a role in the development of AF by inducing left atrial (LA) fibrosis. In this study, we aim to compare anti-M2-R levels between paroxysmal lone AF patients and healthy control subjects and to investigate the relationship between pre-ablation anti-M2-R level, LA fibrosis quantified by delayed enhancement magnetic resonance imaging (DE-MRI), and AF recurrence following cryoablation.