M2-muscarinic acetylcholine receptor autoantibody levels predict left atrial fibrosis severity in paroxysmal lone atrial fibrillation patients undergoing cryoablation


Gurses K. M. , Yalcin M. U. , Kocyigit D. , Kesikli S. A. , Canpolat U. , YORGUN H. , ...Daha Fazla

EUROPACE, cilt.17, sa.2, ss.239-246, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1093/europace/euu228
  • Dergi Adı: EUROPACE
  • Sayfa Sayıları: ss.239-246

Özet

Aims Atrial fibrosis has been found to be associated with recurrent atrial fibrillation (AF) following catheter ablation. Autoantibodies against M2-muscarinic receptors (anti-M2-R) may play a role in the development of AF by inducing left atrial (LA) fibrosis. In this study, we aim to compare anti-M2-R levels between paroxysmal lone AF patients and healthy control subjects and to investigate the relationship between pre-ablation anti-M2-R level, LA fibrosis quantified by delayed enhancement magnetic resonance imaging (DE-MRI), and AF recurrence following cryoablation.