M2-muscarinic acetylcholine receptor autoantibody levels predict left atrial fibrosis severity in paroxysmal lone atrial fibrillation patients undergoing cryoablation

Gurses K. M., Yalcin M. U., Kocyigit D., Kesikli S. A., Canpolat U., YORGUN H., ...More

EUROPACE, vol.17, no.2, pp.239-246, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1093/europace/euu228
  • Journal Name: EUROPACE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.239-246
  • Keywords: Atrial fibrillation, Cryoablation, M2-muscarinic receptor autoantibodies, Atrial fibrosis, DELAYED ENHANCEMENT MRI, CATHETER ABLATION, MUSCARINIC RECEPTORS, ASSOCIATION, MANAGEMENT, FAILURE, TRIAL
  • Hacettepe University Affiliated: Yes


Aims Atrial fibrosis has been found to be associated with recurrent atrial fibrillation (AF) following catheter ablation. Autoantibodies against M2-muscarinic receptors (anti-M2-R) may play a role in the development of AF by inducing left atrial (LA) fibrosis. In this study, we aim to compare anti-M2-R levels between paroxysmal lone AF patients and healthy control subjects and to investigate the relationship between pre-ablation anti-M2-R level, LA fibrosis quantified by delayed enhancement magnetic resonance imaging (DE-MRI), and AF recurrence following cryoablation.