Serum levels of MMP-9 and TIMP-1 in primary hypertension and effect of antihypertensive treatment

Onal I. K., ALTUN B., Onal E. D., Kirkpantur A., ÖZ Ş. G., Turgan C.

EUROPEAN JOURNAL OF INTERNAL MEDICINE, vol.20, no.4, pp.369-372, 2009 (SCI-Expanded) identifier identifier identifier


Background: Matrix metalloproteinases, a family of proteolytic enzymes are thought to be involved in extracellular matrix accumulation during development of hypertensive target organ disease. The present study was designed to compare hypertensive patients with normotensive individuals with respect to serum levels of matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 and to search for the effect of anti hypertensive treatment on the serum enzyme levels.