The purpose of this study was to investigate the effect of home care service on the sexual satisfaction of patients with gynecologic cancer. Sexual health and sexual satisfaction was greatly affect in patients with gynecological cancer depending on the disease and its treatments. Prospective randomized case control study. This study was conducted with 70 patients, of whom 35 patients were in the intervention and 35 patients were in the control group. Data were collected using An Interview Questionnaire, Home Visit Monitoring Questionnaire and Golombok Rust Inventory of Sexual Satisfaction. The intervention group patients were provided with the nursing care service through hospital and home visits (1st and 12th weeks) within the framework of a specifically developed nursing care plans. The control group was monitored without any intervention through the hospital routine protocols (1st and 12th weeks). Data were evaluated using Chi square, McNemar's, independent t test and one-way ANOVA tests. It was found that, within the 12-week post-discharge monitoring period as compared with the time before treatment, patients within the intervention group (those receiving home care services) experienced fewer sexual problems as compared to the control group (patients not receiving home care services). This study found home care services to be efficient in improving the sexual health and sexual satisfaction of patients with gynecological cancer.