Clinical Features of Candidiasis in Patients With Inherited Interleukin 12 Receptor beta 1 Deficiency

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Ouederni M., Sanal O., Ikinciogullari A., Tezcan I., Dogu F., Sologuren I., ...More

CLINICAL INFECTIOUS DISEASES, vol.58, no.2, pp.204-213, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1093/cid/cit722
  • Journal Name: CLINICAL INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.204-213
  • Hacettepe University Affiliated: Yes

Abstract

Background. Interleukin 12R beta 1 (IL-12R beta 1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin 12-dependent interferon gamma production. About 25% of patients also display mucocutaneous candidiasis, probably owing to impaired interleukin 23-dependent interleukin 17 immunity. The clinical features and outcome of candidiasis in these patients have not been described before, to our knowledge. We report here the clinical signs of candidiasis in 35 patients with IL-12R beta 1 deficiency.