Investigation of Gelatinase Gene Expression and Growth of Enterococcus faecalis Clinical Isolates in Biofilm Models

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KART D., Kustimur A. S.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.16, no.3, pp.356-361, 2019 (ESCI)

• Publication Type: Article / Article
• Volume: 16 Issue: 3
• Publication Date: 2019
• Doi Number: 10.4274/tjps.galenos.2018.69783
• Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
• Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.356-361
• Hacettepe University Affiliated: Yes

Abstract

Objectives: Enterococcus faecalis is the major reason for biofilm-related infections and it also interacts with Staphylococcus aureus in biofilms. Gelatinase (gelE) enzyme is an important virulence factor of E. faecalis for biofilm formation. This study aimed to compare the biofilm producing E. faecalis isolates from urine and urinary catheters. The influence of S. aureus on the growth of E. faecalis biofilm cells was also investigated in a dual biofilm model in vitro. Another aim was to evaluate E. faecalis gelE gene expression during biofilm formation.