Effects of intracisternal tramadol on cerebral and spinal neuronal cells in rat


Kose E. A. , Bakar B., Ayva S. K. , Kilinc K., Apan A.

MINERVA ANESTESIOLOGICA, vol.80, no.8, pp.904-912, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 8
  • Publication Date: 2014
  • Title of Journal : MINERVA ANESTESIOLOGICA
  • Page Numbers: pp.904-912

Abstract

Background. The aim was to investigate whether tramadol had toxic effect on cerebral neurons and/or spinal cord neurons when it was administered into the cerebrospinal fluid. Due to lipid peroxidation (LPO) and myeloperoxidation (MPO) levels are not specific predictors of neuronal damage, these biochemical markers of tissue damage were evaluated together with the histopathological findings of apoptosis.