Effects of intracisternal tramadol on cerebral and spinal neuronal cells in rat

Kose E. A., Bakar B., Ayva S. K., Kilinc K., Apan A.

MINERVA ANESTESIOLOGICA, vol.80, no.8, pp.904-912, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 8
  • Publication Date: 2014
  • Journal Name: MINERVA ANESTESIOLOGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.904-912
  • Hacettepe University Affiliated: Yes

Abstract

Background. The aim was to investigate whether tramadol had toxic effect on cerebral neurons and/or spinal cord neurons when it was administered into the cerebrospinal fluid. Due to lipid peroxidation (LPO) and myeloperoxidation (MPO) levels are not specific predictors of neuronal damage, these biochemical markers of tissue damage were evaluated together with the histopathological findings of apoptosis.