JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, vol.13, no.3, pp.269-275, 2021 (Journal Indexed in SCI)
Article / Article
Title of Journal :
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
Newborn screening, children, congenital hypothyroidism, Na-L thyroxine, dose, THYROID-HORMONE REPLACEMENT, CHILDREN, INFANTS, OVERTREATMENT, LEVOTHYROXINE, THERAPY, TSH
Objective: Initial high-dose sodium levothyroxine (Na-LT 4) (10-15 mu g/kg/day) replacement for primary congenital hypothyroidism (CH) is recommended in guidelines. However, high-dose Na-LT 4 risks iatrogenic hyperthyroidism. The aim of this study was to investigate the normalizing effect of varying initial doses of Na-LT 4 on serum thyroid hormone levels.