JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.13, sa.3, ss.269-275, 2021 (SCI-Expanded)
Objective: Initial high-dose sodium levothyroxine (Na-LT 4) (10-15 mu g/kg/day) replacement for primary congenital hypothyroidism (CH) is recommended in guidelines. However, high-dose Na-LT 4 risks iatrogenic hyperthyroidism. The aim of this study was to investigate the normalizing effect of varying initial doses of Na-LT 4 on serum thyroid hormone levels.