The purpose of this study was to evaluate the effects of ultrasonic and manual placement techniques on the push-out bond strength of Biodentine and MTA with and without calcium chloride. One hundred and twenty mid-root slices from forty freshly extracted single-rooted human mandibular premolar teeth were instrumented and randomly divided into six groups (n=20) according to the filling material and placement technique applied, as follows: Gl: MTA-manual compaction, G2: Biodentine-manual compaction, G3: MTA+5% CaCl2-manual compaction, G4: MTA-ultrasonic activation, G5: Biodentine-ultrasonic activation, G6: MTA+5% CaCl2 ultrasonic activation. The push-out bond strengths were measured using an Instron testing machine. Data were analyzed using twoway analysis of variance (ANOVA) with Bonferroni correction. The ultrasonic activation significantly enhanced the bond strength values of the materials. Biodentine presented higher bond strength values than that of MTA groups. The addition of CaCl2 to MTA did not improve the bond strength of the material.