The objective of this study is to highlight the stress factors influencing primary school female teachers in southern Punjab, Pakistan. A causation model is developed to determine the effect of the three main domains of stress. Data were collected through a questionnaire using a convenient sampling technique. Cronbach's alpha is computed to determine the internal consistency of the items of the questionnaire. The factors involved in the causation model are confirmed through confirmatory factor analysis. The perceived stress scale is used to check the stress level in primary school female teachers. A structural pathway of social, health and environmental factors is designed to determine the influence of different variables on stress. The examined problems included the four following major areas: social factors, economic factors, health factors and environment factors. Among our results, it is shown that the marital status has an effect on the stress level of both public and private female school teachers.