FTOgene-lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population

IŞGIN ATICI K., Alsulami S., TURAN DEMİRCİ B., Surendran S., ŞENDUR S. N., LAY İ., ...More

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, vol.72, no.3, pp.375-385, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1080/09637486.2020.1802580
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE, SportDiscus, Veterinary Science Database
  • Page Numbers: pp.375-385
  • Keywords: FTO gene variant, obesity, gene-diet interaction, adiponectin, genetic risk score, physical activity, CARDIOVASCULAR RISK-FACTORS, BODY-MASS INDEX, PHYSICAL-ACTIVITY, FTO GENE, FAT MASS, ENDOTHELIAL DYSFUNCTION, VARIANT RS9939609, DIETARY-INTAKE, WEIGHT-LOSS, ASSOCIATION
  • Hacettepe University Affiliated: Yes


The aim of the study was to investigate whether lifestyle factors modify the association between fat mass and obesity-associated(FTO)gene single nucleotide polymorphisms (SNPs) and obesity in a Turkish population. The study included 400 unrelated individuals, aged 24-50 years recruited in a hospital setting. Dietary intake and physical activity were assessed using 24-hour dietary recall and self-report questionnaire, respectively. A genetic risk score (GRS) was developed usingFTOSNPs, rs9939609 and rs10163409. Body mass index and fat mass index were significantly associated withFTOSNP rs9939609 (p = 0.001 andp = 0.002, respectively) and GRS (p = 0.002 andp = 0.003, respectively). The interactions between SNP rs9939609 and physical activity on adiponectin concentrations, and SNP rs10163409 and dietary protein intake on increased waist circumference were statistically significant (P-interaction = 0.027 andP(interaction) = 0.044, respectively). Our study has demonstrated that the association betweenFTOSNPs and central obesity might be modified by lifestyle factors in this Turkish population.