Vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGFR-3 and D2-40 expressions in primary breast cancer: Association with lymph node metastasis


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EROĞLU A., Ersoz C., Karasoy D., SAK S.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, vol.26, no.2, pp.245-249, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.17219/acem/58784
  • Journal Name: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.245-249
  • Keywords: breast cancer, metastasis, VEGF, D2-40, FACTOR-C, LYMPHANGIOGENESIS, CARCINOMA, ANGIOGENESIS, PROGNOSIS, DENSITY
  • Hacettepe University Affiliated: Yes

Abstract

Background. Two members of the vascular endothelial growth factor (VEGF) family, VEGF-C and -D, are known as lymphangiogenic growth factors and play an important role in tumor lymphangiogenesis via activation of the VEGF receptor (VEGFR)-3, which is expressed in lymphatic endothelial cells. D2-40 is a specific antibody for lymphatic vessel density (LVD).