A big picture of the mitochondria-mediated signals: From mitochondria to organism

Vardar Acar N., ÖZGÜL R. K.

Biochemical and Biophysical Research Communications, vol.678, pp.45-61, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 678
  • Publication Date: 2023
  • Doi Number: 10.1016/j.bbrc.2023.08.032
  • Journal Name: Biochemical and Biophysical Research Communications
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, Veterinary Science Database
  • Page Numbers: pp.45-61
  • Keywords: Cellular stress, Mitochondrial crosstalk, Mitochondrial functions, Mitochondrial signaling transduction
  • Hacettepe University Affiliated: Yes


Mitochondria, well-known for years as the powerhouse and biosynthetic center of the cell, are dynamic signaling organelles beyond their energy production and biosynthesis functions. The metabolic functions of mitochondria, playing an important role in various biological events both in physiological and stress conditions, transform them into important cellular stress sensors. Mitochondria constantly communicate with the rest of the cell and even from other cells to the organism, transmitting stress signals including oxidative and reductive stress or adaptive signals such as mitohormesis. Mitochondrial signal transduction has a vital function in regulating integrity of human genome, organelles, cells, and ultimately organism.