An evaluation of the change in serum SCUBE-1 levels with CPAP treatment in patients with severe obstructive sleep apnea

Ilden, Oguzhan; Selcuk, HANDE; Ellidag, Hamit; Türkoglu Selcuk, Nursel; Eyigor, Hulya; Renda, Levent; Isik, Unal; Unlü, HANDE; OSMA, ÜSTÜN; Yılmaz, Mustafa; Eren, Esin; Yilmaz, Necat

doi:10.1080/08869634.2022.2145710

An evaluation of the change in serum SCUBE-1 levels with CPAP treatment in patients with severe obstructive sleep apnea

Atıf İçin Kopyala

Ilden O., Selcuk O. T., Ellidag H. Y., Türkoglu Selcuk N., Eyigor H., Renda L., ...Daha Fazla

Cranio - Journal of Craniomandibular and Sleep Practice, 2022 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Basım Tarihi: 2022
Doi Numarası: 10.1080/08869634.2022.2145710
Dergi Adı: Cranio - Journal of Craniomandibular and Sleep Practice
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE
Anahtar Kelimeler: Obstructive sleep apnea, SCUBE-1, polysomnography, CPAP
Hacettepe Üniversitesi Adresli: Evet

Özet

© 2022 Taylor & Francis Group, LLC.Objective: Signal peptide CUB-EGF domain-containing protein 1 (SCUBE-1) is a cell surface protein, wherein inflammation causes an increase in serum. The aim of this study was to compare serum SCUBE-1 levels in OSA patients and to investigate the serum SCUBE-1 change with CPAP treatment. Methods: Blood samples were obtained from 61 severe OSA patients and from 25 control subjects evaluated as simple snorers. The 61 patients with severe OSA were treated with CPAP therapy and were recalled for follow up after 1 year. Evaluation was made after 1 year of CPAP therapy. Results: Serum SCUBE-1 values were significantly higher in patients with severe OSA. The SCUBE-1 values significantly decreased after treatment with CPAP. Conclusion: Serum SCUBE-1 values in OSA patients showed a significant reduction in SCUBE-1 levels following 1 year of CPAP treatment.